Companion diagnostics are essential to the success of personalized<br>medicine. For example, the electronic glucose sensor is a success<br>story of companion diagnostics, and millions of diabetic patients<br>around the world today are benefiting from the device in monitoring<br>their health and making informed decisions about medications and<br>treatment strategies. If used properly, companion diagnostic tools<br>can help to change our dietary habits, lifestyle, or exercise<br>routines for disease prevention. With the rapid advances made in<br>high throughput molecular biology, such as genomics, proteomics, and<br>metabolomics, in the past two decades, scientists, researchers and<br>engineers are beginning to harvest the power of ‘–omicsÂ’ to develop<br>companion diagnostic circuits and systems that can be used to<br>diagnose, monitor or predict not just one disease, but multiple<br>diseases simultaneously, as well as allow the management of disease<br>at the personal level, i.e., accordingly to the biology of<br>individual patients.<br>Foreseeing this emerging trend, the purpose of this special issue<br>is: (i) to provide a road map of ‘–omicsÂ’ networks, circuits and<br>systems; (ii) to encourage cross–disciplinary collaboration in this<br>emerging research field; and (iii) to report the cutting edge<br>development of these circuits and devices with translational<br>potential into the clinics. Manuscripts describing original research<br>as well as reviews of emerging directions are solicited for this<br>special issue, covering a range of circuits and systems related<br>‘–omicsÂ’ topics including but not limited to:<br>• DNA, RNA, proteins and small molecule sensors for companion diagnostics;<br>• Technologies for ‘–omicsÂ’ measurements;<br>• Micro/nanofluidics technologies related to omics;<br>• Healthcare and social impact of ‘–omicsÂ’ circuits and systems;<br>• Innovative circuit/system designs using ‘–omicsÂ’ theories and principles, such as gene circuits and self–assembling DNA circuits, biochemical network modules;<br>• Circuit based modeling and simulation of ‘–omicsÂ’ systems such as gene regulatory and signaling networks;<br>• Novel molecular sensing and imaging techniques for on–the–spot molecular diagnosis;<br>• Portable devices for companion diagnostics;<br>• Other ‘–omicsÂ’ methodologies and applications in personalized care delivery.<br>
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